StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

Abstract

This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89%, 82.35% and 11.76%, respectively, for the patient group and 71.76%, 23.51% and 4.71%, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type). These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.