Studying the Prevalence of Multidrug Resistant Klebsiella pneumoniae in Kirkuk City

Abstract

Klebsiella pneumonia is an opportunistic pathogen causes several diseases including sepsis, pneumonia, and wound infections. There are two pathotypes of Klebsiella pneumonia: classical K. pneumoniae (cKp) and hypervirulent K. pneumonia (hvkp), which is an emerging variant of (ckp), clinically distinguished by invasive and multiple site infections. K.pneumoniae is also responsible for majority of human infections, and can infected healthy members of the community and hospitalized patients. A total 150 samples were collected from different hospitals in Kirkuk city during the period between November 2021 to June 2022. The age of patients ranged between (1– 60) years old with both sexes. These samples were highly recovered from females with a rate 66.67% compared to the males 33.33%. Thirty K. pneumonia (20%) was recovered from different clinical specimens including urine, sputum, burn and wound swabs. The current study reported that females are more likely to be infected with K. pneumoniae than man. Likewise, the most common age group infected with K.pneumoniae was between (20-40) with a rate of 63.33%. K.pneumoniae was commonly recovered from inpatients 53.33% compared with outpatients (46.67%). Antibiotic susceptibility test was conducted to all the isolates by using disc diffusion test towards 8 antimicrobial agents. Klebsiella pneumoniae isolates showed multiple resistance against 3 or more of different antibiotic groups such as gentamicin 93%, ampicillin 96% and amoxicillin –clavulanate 90%, cefotaxime 83%, ceftazidime 96%, meropenem 36%, levofloxacin 76 %and gentamicin 93 %. K. pneumoniae isolated from inpatients and from sputum samples were more resistance to various kinds of antibiotics.