Abstract
Studying The Expression of Glucose Transporter Type 1 in the Histological Grades of Oral Squamous Cell Carcinoma
Highlights
One of the widespread features of human malignant tumors, including oral carcinoma, is the overexpression of glucose transporters, Glut-1
This study aimed at investigating the prognostic value of Glucose transporter 1 expression in various histological grades of the oral squamous cell carcinoma (OSCC)
Materials and Methods: 45 Paraffin blocks, belonged to 45 patients who were diagnosed with OSCC, were selected for immune stain GLUT-1 test at the Pathology Department, Damascus University
Summary
One of the widespread features of human malignant tumors, including oral carcinoma, is the overexpression of glucose transporters, Glut-1. Objectives: This study aimed at investigating the prognostic value of Glucose transporter 1 expression in various histological grades of the oral squamous cell carcinoma (OSCC). Conclusions: As histological grades of OSCC increased, there were higher immune-histochemical staining scores. It can be relied on Glut-1 as a marker for the histological grades of OSCC, and the relevant overexpression can signify the malignant behavior of tumor. The primary source of energy for cells is represented by glucose, and it is generally broken into water and carbon dioxide to produce ATP in the presence of oxygen. Malignant cells consume glucose through glycolytic pathway, which enhances a condition of hypoxia
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