Abstract
Introduction: Dihydropyrimidinone (DHPM) is a very useful moiety with a wide range of applications. Synthesis of this moiety with environmentally friendly methods is the demand of the era. Method: In recent research, the optimisation of curd as a biocatalyst has been studied. It has been reported that it can be used directly in the multicomponent Biginelli synthesis of ethyl 6-methyl-2- oxo-4-benzyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates under mild reaction conditions. Result: The chemical structures of synthesized compounds were characterized by physicochemical and analytical methods (1H NMR, IR and LC-MS methods) and it was found that curd is suitable for a vast variety of aromatic aldehydes to obtain the corresponding DHPMs. Conclusion: This new eco-friendly approach can be implemented to synthesize DHPMs for different applications.
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