Abstract
Introduction: Dihydropyrimidinone (DHPM) is a very useful moiety with a wide range of applications. Synthesis of this moiety with environmentally friendly methods is the demand of the era. Method: In recent research, the optimisation of curd as a biocatalyst has been studied. It has been reported that it can be used directly in the multicomponent Biginelli synthesis of ethyl 6-methyl-2- oxo-4-benzyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates under mild reaction conditions. Result: The chemical structures of synthesized compounds were characterized by physicochemical and analytical methods (1H NMR, IR and LC-MS methods) and it was found that curd is suitable for a vast variety of aromatic aldehydes to obtain the corresponding DHPMs. Conclusion: This new eco-friendly approach can be implemented to synthesize DHPMs for different applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
