Abstract
Purpose: Depression causes dysfunction in various spheres of individual and social life, which is now considered as the fourth-leading cause of the global disease burden. Given that violence and aggression associated with depression in the community cause serious damage to the family, the prediction, early detection and effective treatment of aggressive and violent behavior are essential. The present study compared the severity of aggression before and after treatment with sertraline in patients with major depression. Methods: This is an intervention type study and the study population consisted of patients with depression and aggression. The sampling included 23 eligible patients. Data were obtained by SCID-I, SCID-II, STAXI-II, BDI-II and was also analyzed using SPSS 23 software. Results: The results showed that depression, anger mood, desire to verbally express anger, controlling anger and anger control before treatment was reduced but the desire for physical expression of anger increased. Conclusion: Obtained results in this research support the effect of Sertraline on reduction of severity of depression, reduction of severity of symptoms of aggression and anger (state of anger, anger feeling, and the tendency to express anger verbally), increased controlling external anger and significantly controlling internal anger. Hence, Sertraline can be found effective in the treatment of patients with depression and aggressive behaviors. Also Sertraline increases tend to cause physical representation of anger, then this issue supports the increase in the euthanasia behavior in primary days of treatment with SSRI that requires more assessments.
Highlights
Mental disorder is an illness with psychological and behavioral protests which cause considerable confusion in the different functional areas and is developed as a result of biological, social, psychological, genetic, physical or chemical disorders
In addition to the problems caused by depression, there is an idea that aggression plays a major role in depression development which has been fused in psychiatric thinking composition.[4]
Since the serotonergic neurotransmitter system is involved in the regulation of aggressive behavior in humans and animals, it can be assumed that anti-depressants affective on this system can be effective in depressed patients with dramatic aggression.[10]
Summary
Mental disorder is an illness with psychological and behavioral protests which cause considerable confusion in the different functional areas and is developed as a result of biological, social, psychological, genetic, physical or chemical disorders. Since the serotonergic neurotransmitter system is involved in the regulation of aggressive behavior in humans and animals, it can be assumed that anti-depressants affective on this system can be effective in depressed patients with dramatic aggression.[10] In their previous study, Mezza et al revealed the reduction of HR and HRV which confirms vagal activity in aggressive patients.[11] In one study, it was found that there is a relationship between decrease in DBP, SBP and HR and increase in the aggressive behavior of preschool children.[12] It was found that SCL was higher in patients with a greater score of aggression, anger triggers driving under the influence at the time of placement.[12] In another study in 2013, Baker et al concluded that reduction of skin conductance activity (SCA) in babies predict aggressive behavior at 3 years of age.[13] Dibajnia and Moghadasin reported that numerous studies show the association between experience and expression of anger, depression, anxiety and stress.[14] Researchers reported that based on Pearson correlation coefficient and stepwise regression analysis of previous results the state of anger, trait of anger and internalized anger expression are the best predictors of depression. Few studies have been conducted on aggression but according to their results, in an acceptable rate it can be concluded that low excitation of the autonomic nervous system is a biomarker of aggression
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