Abstract
Background: Polycystic ovarian syndrome (PCOS) is the most common cause of anovulation and it also causes other metabolic and endocrinal disorders. Lines of management of PCOS include several medical options in addition to laparoscopic ovarian diathermy (LOD). However, the effect of LOD on ovarian reserve has always been a concern. Advocates to LOD claimed that the decrease in ovarian reserve following LOD is merit not a drawback. Study Design: A case series study aimed at investigating the effect of LOD on Anti-Mullerian hormone (AMH) and trying to find the relation between AMH levels and success of LOD. Patients and Methods: The study was carried out on 30 clomiphene citrate resistant PCOS patients from EL Shatby maternity hospital. Hormonal profile including; FSH, LH, free testosterone, AMH and progesterone was done preoperatively and 3 months after LOD. Results: After LOD 19/30 cases (63.3%) had spontaneous ovulation. After LOD the mean AMH decreased significantly from 9.12 ng/ml to 7.66 ng/ml (p = 0.006*). Responders had significantly lower preoperative AMH as compared to non-responders (8.01 ng/ml Vs 10.01 ng/ml). Responders had a highly significant (p Conclusion: Measurement of serum AMH concentration before LOD may be a useful tool in predicting responders to LOD and help in patient selection.
Highlights
Polycystic ovarian syndrome (PCOS) is the most common pathologic cause of menstrual disturbance in females in the reproductive age
While in non-responders there was no significant change in Anti-Mullerian hormone (AMH) after laparoscopic ovarian diathermy (LOD)
Using ROC curve, pre-treatment AMH level of 7.7 ng/ml is a moderate predictor for patients who ovulated after LOD
Summary
Polycystic ovarian syndrome (PCOS) is the most common pathologic cause of menstrual disturbance in females in the reproductive age. It was found that PCOS patients have high AMH and the severity of the endocrinal abnormalities in these patients is positively correlated to AMH levels. Polycystic ovarian syndrome (PCOS) is the most common cause of anovulation and it causes other metabolic and endocrinal disorders. Lines of management of PCOS include several medical options in addition to laparoscopic ovarian diathermy (LOD). Study Design: A case series study aimed at investigating the effect of LOD on Anti-Mullerian hormone (AMH) and trying to find the relation between AMH levels and success of LOD. Responders had a highly significant (p < 0.01) decrease in AMH post LOD while non-responders did not have a significant change in AMH level in responders. Using ROC curve, pre-treatment AMH level of 7.7 ng/ml is a moderate predictor for patients who ovulated after LOD. Conclusion: Measurement of serum AMH concentration before LOD may be a useful tool in predicting responders to LOD and help in patient selection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
