Abstract
Background: The antibacterial, antifungal and antiparasitic activities of some novel benzosultams and benzosultones in vitro systems are tested. The antibacterial activity has been tested against gram negative bacterium Escherichia coli (E. coli) and gram positive Bacillus subtilis (B. subtilis). The antifungal activity has been tested against an opportunistic pathogenic fungal strain namely Pichia guilliermondii SNP3S. The antiparasitic activity has been tested against filarial parasite Setaria cervi. The active compound 4,7-dimethyl-3,4,7,8-tetrahydro-3λ6-[1,2]thiazino[4,3-f]quinoline-3,3,8-trione was found to exert no toxicity when tested on rat peritoneal macrophage culture. The compounds show moderate to excellent biological activities. The molecular modeling has also been done to compare their inhibitory affinity on human matrix metalloproteinase 9 (MMP-9). Keywords: Antibacterial, antifungal, antiparasitic, benzosultams, benzosultones, molecular modeling, binding affinity.
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