Studying the association of plasma S100A12 and noninfectious pulmonary complication in infants and young children following cardiopulmonary bypass (HUM1P.305)

Abstract

Abstract Objective To examine the kinetics of plasma S100A12 and sRAGE in infants and young children with CPB, and to investigate whether they could predict the occurrence of noninfectious pulmonary complication (NPC) after cardiac surgery. Methods 20 patients were in NPC group, which included pleural effusion, chylothorax, partial lung collapse, pulmonary hypertensive crisis, airway disorders, pneumothorax, pneumomediastinum, and phrenic nerve palsy, and 40 patients in no-NPC group. Plasma S100A12 and sRAGE were measured at 6 perioperative time points. Results S100A12 and sRAGE increased immediately after CPB (P<0.001). SRAGE dropped to lower than baseline level (P<0.05), while S100A12 was still at high level 24h after operation (P<0.001). S100A12 and sRAGE immediately after CPB in NPC group were significantly higher than no-NPC group (P<0.05). S100A12 were still higher in NPC group than no-NPC at 24h after operation (P<0.01). S100A12 immediately after CPB was a predictor for postoperative NPC (OR=1.042, 95% CI: 1.010-1.076, P=0.011). S100A12 immediately after CPB were positively associated with MV time (r=0.47, P<0.001), duration of surgical Intensive Care Unit (r=0.407, P=0.002) and hospital stay (r=0.421, P=0.001). Conclusions Plasma S100A12 and sRAGE were significantly increased immediately after CPB; The elevated S100A12 immediately after CPB served as an early reliable biomarker of the occurrence and the prognosis of NPC after CPB in infants and young children.