Abstract
The gram-positive pathogen Streptococcus pyogenes carries genes encoding previously unidentified but likely virulence factors, including two macrolide efflux proteins, according to Anne E. Kizy and Melody N. Neely from Wayne State University School of Medicine in Detroit, Mich. These virulence factors were uncovered by studying what happens to zebrafish when infected by these bacteria, one among a variety of streptococci that sometimes cause necrotizing fasciitis, which in humans severely damages the skin. Details appear in the May Infection and Immunity (77:1854–1865).
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