Abstract
Liver regeneration in mammals is a unique phenomenon attracting scientific interest for decades. It is a valuable model for basic biology research of cell cycle control as well as for clinically oriented studies of wide and heterogeneous group of liver diseases. This article provides a concise review of current knowledge about the liver regeneration, focusing mainly on rat partial hepatectomy model. The three main recognized phases of the regenerative response are described. The article also summarizes history of molecular biology approaches to the topic and finally comments on obstacles in interpreting the data obtained from large scale microarray-based gene expression analyses.
Highlights
The liver regeneration attracts scientific attention for decades as a unique phenomenon in mammalian physiology
The aim of this article is to provide a brief review of current understanding of the mechanisms of liver regeneration, list molecular biology approaches employed in this field and to bring a discussion of challenges arising when interpreting the results of recent microarray gene expression analyses
That the liver regeneration process after the loss of functional mass consists of three fundamental phases: a) initiation or priming, progression of the quiescent hepatocytes to repeated division, b) proliferative phase, restoring the liver tissue to its volume before an insult and c) termination of growth and balancing the resultant size of the liver to just comply with functional demands of the organism [14]
Summary
STUDYING LIVER REGENERATION BY MEANS OF MOLECULAR BIOLOGY: HOW FAR WE ARE IN INTERPRETING THE FINDINGS?. Summary: Liver regeneration in mammals is a unique phenomenon attracting scientific interest for decades. It is a valuable model for basic biology research of cell cycle control as well as for clinically oriented studies of wide and heterogeneous group of liver diseases. This article provides a concise review of current knowledge about the liver regeneration, focusing mainly on rat partial hepatectomy model. The article summarizes history of molecular biology approaches to the topic and comments on obstacles in interpreting the data obtained from large scale microarray-based gene expression analyses
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