Abstract
We explore how hallucinations might be studied within the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which asks investigators to step back from diagnoses based on symptoms and focus on basic dimensions of functioning. We start with a description of the objectives of the RDoC project and its domains and constructs. Because the RDoC initiative asks investigators to study phenomena across the wellness spectrum and different diagnoses, we address whether hallucinations experienced in nonclinical populations are the same as those experienced by people with psychotic diagnoses, and whether hallucinations studied in one clinical group can inform our understanding of the same phenomenon in another. We then discuss the phenomenology of hallucinations and how different RDoC domains might be relevant to their study. We end with a discussion of various challenges and potential next steps to advance the application of the RDoC approach to this area of research.
Highlights
There is evidence for cognitive and neurobiological alterations in contextually bound declarative memory in people diagnosed with schizophrenia who experience auditory hallucinations (AHs).[31] One approach to understanding the role of this construct in AHs might be to study activity in memory-related circuits during AHs in a range of people whose hallucinatory experiences vary according to whether their AHs involve memories
We explore how hallucinations might be studied within the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which asks investigators to step back from diagnoses based on symptoms and focus on basic dimensions of functioning
We explored how auditory hallucinations (AHs) might be studied within NIMH’s RDoC framework
Summary
There is evidence for cognitive and neurobiological alterations in contextually bound declarative memory in people diagnosed with schizophrenia who experience AHs.[31] One approach to understanding the role of this construct in AHs might be to study activity in memory-related circuits during AHs in a range of people whose hallucinatory experiences vary according to whether their AHs involve memories.
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