Abstract
A previously undescribed phenyl-substituted iodo-δ-lactone of 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized using the Ti-catalyzed intermolecular cross-cyclomagnesiation of an aromatic 1,2-diene with an O‑containing allene at the key stage in a 94% yield. The in vitro cytotoxic activity of the obtained alkyl- and phenyl-substituted iodo-δ-lactones 5Z,9Z-dienoic acids was studied in relation to the cell lines Jurkat, K562, U937, HL60, Hek293, and the effect on the cell cycle and the ability to induce apoptosis with using flow cytometry.
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More From: Доклады Российской академии наук. Химия, науки о материалах
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