Studying and Evaluating the Immune System in Urticaria, Asthma and Rhinitis

Abstract

Background: Diseases related with allergy such as urticaria, asthma, and rhinitis have an effect onautoimmune system.Objectives: This study was planned and carried out to assess how the immunity affected in patients withallergy and urticaria, asthma, and rhinitis through measuring the total IgE and IL-33.Materials and Method: A collection of females and males (74 patients) with urticaria, asthma, and rhinitiswere chosen in this research, 24 with urticaria, 26 with asthma, and 24 with rhinitis their ages were rangedfrom 30 to 45 years while their weight ranged from 69 to 92 kg, using immuno sorbent assay (ELISA),the IL-33 and IgE were calculated and evaluated respectively in the patients and the collected data werecompared with healthy individuals (control).Results: The data that was gathered from the blood serum of urticaria, asthma, and rhinitis patients indicatesconsiderable differences in levels of IL-33 which were tolerated from172 to 185 Ng/l, while the IgE rangedfrom 321 to 397 Ng/l comparing with healthy individuals (control). Also results of specific IgE signify aexistence for one or more inhalant allergens in urticaria, asthma, and rhinitis, especially in rhinitis patients,precisely in Weeds allergens (w6, w9), Tree allergens (t2, t3, t4, t7), and Grasse’s allergens (g6, g12) and itwas lower in females than males.Conclusion: The considerable changes in the IL-33, and IgE in the patients affect the immunity system inthe patients due to the chronic inflammatory diseases (urticaria, asthma, and rhinitis) and it will increased inpatients with inhalant allergy.