Abstract
Many essential receptor proteins, such as ligand-gated ion channels, function via complicated conformational modulation to mediate electrochemical signal transduction in the nervous system. Dysfunction of these proteins is associated with various disorders, which emphasizes how crucial it is to understand the mechanism of action of such neuroreceptors in order to design modulators with diagnostic or therapeutic applications. Recent advances in structural biology have enabled the determination of newly detailed structures of ligand-gated channels, including glycine receptors, principal mediators of neuroinhibition in the spinal cord and brainstem.
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