STUDY TO EVALUATE THYROID LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract

Background- Chronic kidney disease is a highly prevalent condition with heightened risk for cardiovascular diseases, infections, impaired physical functions and death. Low T3 levels are the most common lab findings followed by subclinical hypothyroidism in CKD patients. Patients with hypothyroidism have clinically important reductions in glomerular filtration rate.Hypothyroidism can also lead to hyperlipidemia & atherosclerosis in coronary and peripheral vessels. Studies indicated that subclinical and clinical hypothyroidism were the risk factors for all cause mortality and CVD death. Objective- To evaluate thyroid levels in Chronic Kidney Disease Patients. Methodology- Study was conducted in Osmania General Hospital. 40 cases of CKD patients formed the study group and 40 normal healthy individuals formed the control group. T3, T4, TSH levels were estimated using Chemiluminiscence Immunoassay. Results- T3 levels were found low in cases (< 0.87ng/ml) as compared to controls.TSH levels were found high (>5.60 micro IU/ml) in cases as compared to controls. No significant difference was found between groups in T4 levels. Conclusion- Patients who are appropriately treated for thyroid diseases have a less chance of developing renal dysfunction.Thus, clinicians should be well educated on the role of thyroid hormones in relation to CKD so that proper treatment can be delivered to the patient.