Abstract
Aim: To investigate the possible antioxidant and hepatoprotective effects of purified extract obtained from aerial parts of Astragalus glycyphyllos (EAG) using in vivo model of CCl 4 - induced liver damage in male Wistar rats. Study Design: A total of 36 animals were randomly allocated in six experimental groups, each consisted of six animals: Control rats ( Group 1), rats challenged orally with CCl 4 (10 % solution in olive oil) ( Group 2), rats treated for 7 days with silymarin (100 mg.kg - 1 , 0.5 mL/100 g) alone ( Group 3) and challenged with CCl 4 after 7 - day pre - treatment with silymarin ( Group 4); animals in groups 5 and 6 were either treated with EAG (100 mg.kg - 1 , 0.5 mL/100 g) alone or challenged with CCl 4 after 7 - day pre - treatment with the extract.
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