Abstract
This study was designed to find the frequency of different abnormalities that can be observed in the results of thyroid function tests in patients with chronic renal failure, who are on hemodialysis, to assess the effect of having chronic renal failure on these frequencies, and to assess effect of age, duration of chronic renal failure, total serum protein level and serum albumin level of the results of thyroid function tests in patients with chronic renal failure, who are on hemodialysis. So that 35 patients with chronic renal failure and on hemodialysis had been randomly selected from those who attended the hemodialysis unit at Al-Yarmouk Teaching Hospital during the period from July 2016 to February 2017, Age and sex matched control had been selected randomly (35 patients). Detailed questionnaire had been applied containing information about the personal information and risk factors. All of the patients investigated for thyroid function tests and total serum protein and serum albumin levels. This study had shown there is general tendency of all thyroid function tests to be low but with the normal range, this tendency had been shown according to age, duration of chronic renal failure, level of serum albumin and total serum protein. Lower T3 levels are associated statistically with older age, and lower serum albumin levels. Lower TSH is associated with older age and higher total serum protein levels.
Highlights
Thyroid hormones are necessary for growth, development, differentiation and metabolism of virtually all tissues of vertebrates (Rucsandra et al, 2014)
Regarding results of thyroid function tests in patients with uremia and on hemodialysis, this study had shown that statistically significant lower mean of total T3 levels had been detected in comparison with that observed in the age and sex matched control
Taking into consideration that the T3 levels which have noticed in patients with CRF were within normal range but more in the lower limits of the normal, and no case of hypothyroidism had been diagnosed in the sample under study
Summary
Thyroid hormones are necessary for growth, development, differentiation and metabolism of virtually all tissues of vertebrates (Rucsandra et al, 2014). Previous studies have shown that CKD patients have low triiodothyronine (T3), normal or reduced thyroxine (T4) levels, and elevated thyroid-stimulating hormone (TSH), Most patients with end stage renal disease have decreased plasma levels of free triidothyronine (T3), which reflect diminished conversion of T4 (thyroxin) to T3 in the periphery. This abnormality is not associated with increased conversion of T4 to the metabolically inactive reverse T3 (rT3), since plasma rT3 levels are typically normal. The frequency of goiter is markedly increased in end-stage renal disease (Joan et al, 2017)
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