Study the Role of Urotensin Ii as a Predictor for Hepatorenal Syndrome

Abstract

1.1.Bakground and Objectives; Chronicliver disease and its complications is a common health problem worldwide. Hepatorenal syndrome (HRS type 1, 2) is one of these serious complications with high mortality.The aim of this study was to evaluate the diagnostic role of urotensin II in patients with chronic liver diseases (both ascitic and non ascitic patients). 1.2.Patientsand Methods: Forty patients were selected from Gastroenterology, Hepatology and Infectious Diseases Department, Benha University Hospital, Egypt. Group (1) 20 patients with ascites (9 males and 11 females), their ages ranged from 35-65years with mean 50.95 ± 9.84. Group (2) 20 patients without ascites as a control group (8 males and 12 females) their ages ranged from 35-63 years with mean 49.25± 9.66, from the period of March 2011 to July 2011. 1.3.Results: There was no statistically significant difference as regard CBC parameters ( p>0.05) between the ascitic group (1) and non ascitic group (2), except for platelet count, there was a statistically significant decrease between the 2 groups (p 0.05). The Ultrasound findings of the kidney's were of statistically significant difference between the two groups as regard nephropathy (8 patients in ascitic group [1] while one patient in non ascitic group [2]) (p value <0.05). There was a statistically significant correlation between Urotensin II and blood urea level in group 2, but there was not with other variables. The cut-off value of Urotensin II was of sensitivity 66.7%, specificity 64.5%, PPV 35.3% and NPP 86.96% with Accuracy 59% and p value <0.42 of no statistically significant difference. Conclusion: Urotensin II was of statistically significant positive correlation with blood urea level in patients with ascites, that means the relevant clinical importance to use urotensin II in the early stages of liver disease before development of HRS. Also it can be used to diagnose subclinical hepatic encephalopathy patients , that is confirmed with other investigation.