Study The Role of Selenium in The P-Selectin and E-Cadherin Serum Levels in Women with Preeclampsia

Abstract

Preeclampsia (PE) is characterized by endothelial dysfunction with vasoconstriction due to cell adhesion molecules or mediators released by defective placentation. Platelet selectin (P-selectin) and epithelial cadherin (E-cadherin) are the cell adhesion molecules, is elevated in many inflammatory conditions including PE.Objective: To investigate if P-selectin and E-cadherin levels can be used as a marker for adverse outcomes in pregnancy complicated with PE.Patients and Method: This study involved 90 pregnant women in their third trimester of pregnancy divided into2 group:Group A: involves 45 pregnant women with PE.Group B: involve 45 healthy pregnant women and normal fetal growth (Control group).Result: The results show there were a high significant increase in the mean values of P-selectin with high increase in the mean values of E-cadherin in PE group when compared to control group.ROC curve shows sensitivity and specificity and false positive rate for predication of PE by P-selectin and E-cadherin in control and patients groups, and the maximum accuracy for the P-selectin and E-cadherin in discrimination between control and PE patients groups.Conclusions: There is an inverse relationship between cell adhesion molecules and selenium in PE compared with normal pregnancy.High level of serum P-selectin and E-cadherin are associated with the presence PE, which provide additional information for predicting of PE and preventing its complications and for better understanding pathogenesis of PE