Abstract
The polymer composites based on Polyvinyl alcohol loaded with different concentrations of commercial curcumin were prepared to be applied forcontrolled release drug delivery system to overcome the growth promotion of tumor cells.The prepared composites were subjected to drug release in aqueous media at room temperature. It was found that the amount of the released curcumin changed according to different pHmedia and the concentration of theloaded drug onto the polymer carrier. The diffusion coefficient of the released curcumin from the prepared composites was found to be 2.739X10-2, 1.638X10-2, and 5.777X10-4 in basic, acidic and neutral solution respectively according to Higuch's equation. The results of the in/vitro cytotoxic activity of the released curcumin showed sustained antiproliferative potency up to 30 % growth inhibition against the human liver cancer cell line (HEPG2) which extended to 25 days.
Highlights
The polymer composites were developed as drug carriers for along time ago.Their applications have tremendously enlarged due to their enhanced loadingpossibilities, stability and the control of the physicochemical properties (Parida et al, 2011; Sahoo et al, 2010)
It is clear from the table that in vitro cytotoxic activity of the released curcumin showed sustained antiproliferative potency up to 30 % growth inhibition against the human liver cancer cell line (HEPG2) which extended to 25 days
Slow release technique is a good mean for fighting cancer cell line
Summary
The polymer composites were developed as drug carriers for along time ago.Their applications have tremendously enlarged due to their enhanced loadingpossibilities, stability and the control of the physicochemical properties (Parida et al, 2011; Sahoo et al, 2010). The localized drug release may be carried outusing macroscopic loaded drug close to the target site. For this approach, in-situ forming biomaterials in response to environmental stimuli have gained significant attention, due to the expanded properties, the decreaseof side effects related toregular administration, and improve the biodistribution of the drug (Mallapragada and Peppas, 1996; Helaly et al, 2015). Polyvinyl alcohol (PVA) is considered as a nontoxic hydrophilicpolymer but alsoit is a water soluble and has the ability for thefilm-forming. Likewise, it has a good physical and. Study the cytotoxic potency against the human liver cancer cell line (HEPG2)
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