Study the predictable correlation between recurrent abortion with the level of proteins S, C, age and blood groups in women in AL-Najaf governorate, Iraq

Abstract

Context: Repeated pregnancy loss is causing great distress to couples and undermining their confidence in achieving reproductive success in the future. A doctor can usually diagnose the cause and manage it directly, but in some cases, the cause is not known. Aim: This study aims to investigate whether there is a correlation between recurrent miscarriage and the level of protein S, C, age and blood groups in women who have experienced recurrent miscarriage without identifying a cause for this condition. Material and methods: one hundred twenty from infected women by recurrent abortion for unknown causes were classified according to age groups. Diagnosed blood group by using a specific kit for Biorex diagnostic Limited (the United Kingdom, 2016). The concentration of protein S and C were calculated by using the equipment produced by the AESKU.DIAGNOSTIC (Germany) Statistical analysis: the statistical analyses of the data were performed by using the (SPSS) 20.0 software package. We used the following analyses, frequencies, percentage, mean, stander diversion and Pearson correlation to identify the potential correlation between the miscarriage and the level of protein S, C, age and blood groups, the p-value of less than 0.05 was considered significant. Results: The study showed that out of a total of 120 women, who suffer from recurrent abortion, 82/120 have a decrease in the level of C protein, 96/120 have a decrease in the level of S protein and 74\120 have low level of both proteins C&S. The results were statistically significant (P=0.000, P=0.000 and p=0.000), There was an intermediate direct correlation between recurrent abortion and the level of proteins C and S (rp= 0.545, rp= 0.643), also there was correlation between the level of protein S and the level of protein C (rp=0.713). It was also found that there was no correlation between age and blood groups with cases of recurrent abortion in women the results was statistically non-significant (rp= - 0.084, p= 0.279; rp= 0.108, p=0.159). Conclusion: There are several reasons for the occurrence of recurrent abortion, including what is caused by microbial infections, or it may be caused by certain abnormalities in the reproductive system, etc., also appear to the results of this research, the low level of one of the proteins S, C or both may be a cause in the case of recurrent abortion.