Study the Level of Interleukin -18 Binding Protein Alpha in Iraqi Arab female Patients with Diabetes Mellitus Type II

Abstract

Diabetes mellitus consider as inflammatory disease associated with many inflammatory factors for that the present study aims to investigate the concentration of IL-18 binding protein alpha with classical risk factors to study their role in Iraqi female patients with diabetes mellitus type2. The study included 60 female patients newly diagnosed with type 2 DM and 28 healthy individuals. The patients mean age was (47.48±1.08) while control mean age was (39.46±1.86). Laboratory tests were include detection of IL18BPa in serum by ELISA kits, chemical parameters which included Fasting blood glucose, Glycosylated haemoglobin and Lipid profile using enzymatic and colorimetric methods, besides anthropometric parameters includes central obesity and body mass index. The present study showed a significant increasing in the serum level of IL-18binding protein alpha between DM type 2 patients and control. Fasting blood glucose, Glycosylated haemoglubin, total Cholesterol, Triglyceride, Low Density Lipoprotein, Very Low Density Lipoprotein and Atherogenic index showed significant increasing levels while a significant decreasing level of high density lipoprotein in sera of patients group compared to control group was observed also the mean of CO and BMI were non significant increased in patients group compared to control group. In conclusion, present study indicates that IL-18 binding protein alpha is an independent risk factor for diabetes mellitus type 2 in Iraqi Arab females. This result supported by the absence of significant correlation among IL-18 binding protein alpha and all others classical risk factors. While the increased level of IL-18 binding protein alpha associated with duration of disease and increased age over than fifty years old for patients and healthy females .Further studies are needed to understanding the relationship among present different factors.