Study the interrelation between monocyte chemoattractant protein-1 (MCP-1) with clinical characteristics of metabolic syndrome patients

Abstract

This study was carried out at Diabetes and Endocrinology Unit in Al-Sader Teaching Hospital in AL-Najaf province /Iraq from January 2019 to July 2019 on metabolic syndrome patients who attended the hospital for monthly checkup. (130) participants have been involved in this study, blood samples were obtained from (90) patients with metabolic syndrome. (50 female and 40 male), and from (40) individuals as a control samples, who were obviously healthy. The age, gender, WC and BMI of the patients and the control is taken during physical exam, lipid profile and blood glucose also estimated for all groups. MCP-1 biomarker in serum was measured by solid phase enzyme-linked immunosorbent assay (ELISA). The aims of this study is find out the relationship between MCP-1serum concentration and some clinical characteristics of MetS patients which include body mass index, waist circumferences, age and gender in Iraqi MetS patients and make comparison between both the males and females MetS patients in metabolic syndrome severity. A significant increase in concentration of serum MCP-1 was revealed by the results of the present study in metabolic syndrome patients in compared with control group. The results showed that MCP-1biomarker concentration had a significant increase in serum of Mets females' group in compared with Mets males' group respectively. In regarding to the age, the study show there is a significant increase in serum MCP-1in Mets females' patients when equated with Mets group of male patients at same age group in [40-49y], [50-59 y] and [60-69 y]. The study also indicates a significantly increase in serum concentrations of MCP-1of Mets females' patients with all different WC groups as compared with the males patient in the same WC.