Abstract
This Study aimed to investigate the effect of garlic extract against multidrug resistance ofStaphylococcus aureus and E. coli isolated from urine. Isolates were identified by usingbiochemical tests. The susceptibility of these microorganisms towards the most effectiveantibiotics were studied by using disc diffusion method. The multidrug resistancemicroorganisms were challenged with garlic extract using serial dilutions and the technology ofELISA spectrophotometer. The results of this study showed that ten isolates of E. coli and eightisolates of Staphylococcus aureus out of sixty isolates were resistant to all antibiotics. Garlicextract significantly inhibits the growth of these bacteria in a concentration independent manner.This study showed that garlic extract exerts a promising antibacterial effect against multidrugresistance of Staphylococcus aureus and E. coli.
Highlights
Garlic (Allium sativum.L) is a plant that belongs to the genus Allium in the family Liliaceae
The results of this study showed that ten isolates of E. coli and eight isolates of Staphylococcus aureus out of sixty isolates were resistant to all antibiotics
This study showed that garlic extract exerts a promising antibacterial effect against multidrug resistance of Staphylococcus aureus and E. coli
Summary
Garlic (Allium sativum.L) is a plant that belongs to the genus Allium in the family Liliaceae. The antibacterial effects of garlic extended to inhibit of both Gram positive and Gram negative as well as molds and yeasts [1, 2, 3].Allicin, a thiosulfinate substance, and the amino acid allicin are the active substances that possessed antibacterial effect [4, 5]. The antibacterial effect of garlic mediated through inhibition of bacterial protein synthesis, RNA, partially DNA and even cell wall [6,7, 8]. The antibacterial activity of garlic on the cell wall quantified to be 1 mg garlic is equipotent to 15. Synergism or additive effect observed when garlic combined with ampicillin whereas the antibacterial effect of ciprofloxacin lost when combined with garlic [10].
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