Abstract
The present study was aimed to detection the histopathological changes on the kidney of male rats treated with sildenafil drug. In this study, 40 adult male rats were used. These rats divided into four equal groups, each group involved ten rats, group I receive normal saline (1ml/Kg) as control group (N= 10). Group II, III and group IIII was received sildenafil orally at a with following concentration of (1.25,2.5 and 5mg/kg) body weight for 3 months respectively. At the end of experiments. All animals are euthanized and both kidney samples are collected for histopathology assessment. The result demonstrate deferent lesion in kidney structures in treated groups involved degeneration and necrosis of cortical renal tubules, Area of cystic dilation in glomeruli. Cystic dilation in renal tubules also the result recorded dilation glomeruli with dilation of bowman space, finally dilation glomeruli’s with degenerate cellularity and calcification of tubules in compared to control group including normal glomeruli and normal renal tubules.
Highlights
IntroductionIt is comes in two forms, those are a suspension (liquid) and a tablet, by mouth, both are taken
When used overdose of sildenafil for long time may cause acute kidney injury, this report in old man (67 year), he was took sildenafil in over dose (400 mg) for erectile dysfunction, this patient affected by acute tubular necrosis in acute kidney injury during hospitalization, as well as the peak of serum creatinine was 5.07 mg/dL during his renal function repair with encouragement care [2,3]
The rats were divided into four groups( group1, group2,group3 and group 4), 10 rat in each group, one of these are untreated as control group, and others three treated groups. (Treated with sildenafil) All group receive normal diets, animals were housed cages in standard home with adequate temperature, ventilation and the experiment was done for three months
Summary
It is comes in two forms, those are a suspension (liquid) and a tablet, by mouth, both are taken. Other form used in IV Route, but is only given by a doctor. This oral tablet drug is available in the brand-name drugs ((Viagra)) and ((Revatio)). As well as available in a generic drug. Approved drug to treat pulmonary hypertension and erectile dysfunction, it’s a phosphodiesterase type 5 inhibitor. Sildenafil in general, is safe but it has some side effects like headaches, heartburn, and flushed skin. Erectile dysfunction (ED) case associated with cardiovascular diseases, including hypertension, diabetes mellitus and atherosclerosis [4]. Detoxification in the liver by the hepatic CYP2C9 and P450 enzymes CYP3A4 converted the sildenafil to a number of metabolites. [5]
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