Study the Genetic Expression of Activin A and Fibrillin-3 in PCOS and Non-PCOS women

Abstract

Polycystic ovarian syndrome (PCOS) is a prevalent and complex endocrine condition that affects 5 to 20% of reproductive-age women and is a leading cause of hirsutism and infertility. Selected 28 women were intentionally divided, according to the cause of infertility, into 14 infertile women with the polycystic ovarian syndrome (PCOS) and 14 non-polycystic ovarian syndromes (Male factor) used as a control group. For each patient, measurement of the fold of expression of Activin A, and Fibrillin-3 hormones, in blood was done on: On the day of the ovum collection and after 14 days of the embryo transfer (ET). The fold of activin an expression in pregnant groups was high compared to the Non-pregnant group for both PCOS and Non-PCOS women on the day of ova pick up while the fold of gene expression in the pregnant group was slightly more compared with the non-pregnant group for non-PCOS women, where the fold of gene expression in pregnant women decreased by compared with non –pregnant for PCOS women. The fold of fibrillin-3 expression in pregnant groups was high compared to the Non-pregnant group for both PCOS and Non-PCOS women, where the fold of gene expression was (0.86,0.84 ) for Non- PCOS, PCOS women respectively, which refers to an increase in FBN-3expression in the pregnant group compared to gene expression in Non-pregnant group.