STUDY THE FIBROSIS AND HYPERTROPHY OF LIGAMENTUM FLAVUM IN LUMBAR SPINAL CANAL STENOSIS DUE TO LEPTIN INDUCED INFLAMMATIO

Abstract

Lumbar spinal stenosis (LSS) is defined as the narrowing of the spinal canal with cord or nerve root impingement and as consequences the symptoms of radiculopathy or pseudoclaudication are developed. Hypertrophy of the ligamentum flavum (LF) is often involved in the pathogenesis of LSS, resulting in the reduction of diameter of the spinal canal and compression of the dural sac and nerve roots.Leptin's important role in various biological functions further than appetite regulation and energy metabolism.Interestingly collective evidence suggests it has a critical role in the fibrosis process in multiple organ systems, including the liver, kidney, and lung. The aim of this study was to establish a relationship between serum leptin levels and the fibrosis and hypertrophy of ligamentum flavum in lumbar spinal canal stenosis. METHOD: Our study include 100 patient with ligamentum flavum hypertrophy with lumbar canal stenosis to evaluate co-relation with increased serum leptin levels. Demographic data, clinical, radiological and laboratory investigation done to find a co-relation between increased serum leptins levels with the fibrosis and hypertrophy of ligamentum flavum in lumbar canal stenosis.RESULT:In our study,LF thickness was also measured with a T1weighted axial MRI.The mean thickness in the high vas scores (> 5) group was signicantly thicker than that in the low vas (< 5) group. Serum leptin values were positively correlated to LF Thickness at L4-L5 (r=0.228) and L5-S1 (r=0.198) level and the correlation was significant (p>0.05). CONCLUSION: Our study has shown strong correlation between serum levels of leptin and hypertrophy of ligamentum flavum.VAS score in low VAS group (< 5) as well as high VAS score group (> 5) are positively correlated with serum levels of leptin