Abstract
Giardia lamblia parasite was isolated from the diarrhea samples of patients with Giardiasis dysentery and was developed in HSP media, four mice groups have been used to find in vivo efficacy of two concentrations (128,256) mg/ml of chlorophorm extracts from Cladophora glomerata algae against Giardia lamblia parasite as compared with (Flagyl) by measuring several biochemical markers as ( GPT and GOT) enzymes ,sodium ,potassium and iron concentration as well as counting the number of parasitic cysts in each mice groups. The results demonstrate that levels of GPTA GOT enzymes have been decreased in mice treated with algal extract. As for the concentration of the Sodium, Potassium and Iron increased in mice treated with algal extract. The number of the Giardia cyst is also reduced in orally inoculated mice with both concentrations of algal extract as compared with positive control and the Flagyl treated group. In terms of bioactive compounds, GC-Mass results indicate the presence of many phytochemicals with different biologically active properties This study represents the first attempt to use Cladophora glomerata derived from phytochemicals to treat giardiasis in vivo.
Highlights
Intestinal parasitic infection is a potential communal health problem distributed around the world mostly in developing countries
Because of the importance of the locally isolated Giardia parasite, several researches have been carried out to find the treatment of patients, so in this study in vivo efficacy of the C. glomerata algae to treat mice infected with this parasite by determining several blood parameters and calculating the number of parasite cysts in feces of infected mice
Results show high levels of liver function enzymes glutamate pyruvate Transminase (Gpt), glutamate oxaloacetic transminase (Got) in serums of mice infected with the parasite, Table 1
Summary
Intestinal parasitic infection is a potential communal health problem distributed around the world mostly in developing countries. These parasite cause many severe symptoms 1. The cyst is an oval which contains two or four nuclei surrounded by a thick wall 3 This parasite infects the upper part of the intestine duodenum and the jejunum trophozoite feed on the intestinal secretions after it sticks to its wall and form a dense cover of flagellates. This leads to molting villi of the small intestine and produces little food absorption and fatty diarrhea 4. Because of the importance of the locally isolated Giardia parasite, several researches have been carried out to find the treatment of patients, so in this study in vivo efficacy of the C. glomerata algae to treat mice infected with this parasite by determining several blood parameters and calculating the number of parasite cysts in feces of infected mice
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