Abstract
Drug delivery using nanocarriers is recommended to decrease the drug amount. To improve the different therapeutic characteristics of curcumin (CU) such as solubility, bioavailability, maintenance endorsement, and make it a promising, successful antitumor drug used for prostate cancer treatment. It was introduced to folate decorated chitosan (CS) coated Fe@Au NPs (FA-CU-CS-Fe@Au NPs). Fe@Au nanoparticle contains magnetic Fe NP’s core with a fine layer of Au NP’s synthesized using the method Pulsed, Laser, Ablation in Liquid (PLAL). These Fe@Au NP’s characterized by UV-Visible Spectrophotometer, High-Resolution, Transmission Electron Microscopy, (HRTEM), and Field Emission Scanning, Electron, Microscopy (FESEM). The smallest nanosize and the best result was obtained at different laser wavelength (532, 1064) nm. The mean size gained of Fe@Au NPs were (67.65, 77.88) nm. Obtained results exhibited that the laser wavelength plays a key role in the size, and dispersity of Fe@Au NPs. CU loaded FA-CS-Fe@Au NPs MTT assay on human prostate cancer cell line (PC3) proved that CU cytotoxicity can improve when they are loaded on (FA-CS-Fe@Au NPs) when comparing it with free CU.
Highlights
Cancer is characterized by the proliferation of uncontrolled cells, in which cells that grow to become an abnormal cell mass is called a tumor
To improve the different therapeutic characteristics of curcumin (CU) such as solubility, bioavailability, maintenance endorsement, and make it a promising, successful antitumor drug used for prostate cancer treatment
CU loaded Folic acid (FA)-CS-fabrication of (Au) shell (Fe)@Au NPs MTT assay on human prostate cancer cell line (PC3) proved that CU cytotoxicity can improve when they are loaded on (FA-CS-Fe@Au NPs) when comparing it with free CU
Summary
Cancer is characterized by the proliferation of uncontrolled cells, in which cells that grow to become an abnormal cell mass is called a tumor. A favorable strategy over recent years appeared to manufacture core-shell iron-gold biocompatible nanomaterials, for usages, they are widely in the biotechnological and biomedical areas, comprise bio-targeting for cancer therapy, drug carriers, bio-detection, and bio-separation [3,4,5,6]. The structures and properties of the production are dominated by modifying conditions of experimental like solutions, external environment, target materials, and laser parameters, the process can be performed at normal temperature and pressure [22,23,24,25]. The purpose of this study is to prepare and synthesized nanoencapsulation as drug delivery by PLAL method with a new formulation of FA-CU-CS-Fe@Au NPs to treat prostate cancer (PC3) and normal cell line (RWPE-1)
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