Abstract
The present investigation aimed to study the Adenosine Deaminase activity in induction Cytogentic and histopathological change in skin and eyes of sumicidine treated rats. The study Included. 1-Adenosine deaminase activity . 2-Total serum protein. 3-Micronuclei in binucleated cell. 4-Histopathological changes in skin and eyes. 
 19 white male rats were used . They are randomly allocated into 3 groups : 1st group was fed 2% sumicidine for 15 days. 2nd group was fed 2% heating sumicidine for 15 days . 3rd group was kept on normal diet. Blood Adenosine Deaminase activity and Total serum protein in 1 and 2 group significantly decreased at 15 and 30 days of treated. The results 
 indicated that sumicidine increased significantly micronucleus in group 1 and 2. Multifocal granulomatous lesions in skin & eyes of group 1 and 2 were found characterized by highly aggregation of cells (Lymphocytes, Macrophages, Foreign body giant cells and fibroblasts). 
 In conclusion , Sumicidine even heated accompaying in decreased in decreased Adenosine Deaminase activity and total serum protein , in part a possible factor in the cytogenetic effect and accompanying granuloma formation in skin and eye .
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