Abstract
This study aimed to find out the current role of free radical and oxidative stress in the events of this disease through the study the determined levels of lipid peroxidation and some of number antioxidents concentrations. The study included (100) patients with Peptic ulcer (50 males and 50 females) as well as (50) people (25) healthy males, 25 females) as a control group.
 (5) ml of blood from the Anticubital vein for the purpose of estimating the concentrations of malondialdehyde (MDA( and peroxinitrate radical (ONOO.-) and some enzymic antioxidants such as catalase (CAT), superoxidismutase (SOD), glutathion peroxidase (G-px) ,and non- enzymic antioxidants such as glutathion (GSH), ceruloplasmin (CP), uric acid , albumin.
 The results showed a significant increase (P≤0.01) in the concentration of the (MDA) and (ONOO.-) and a significant decrease in the concentration of the (CAT), (SOD), (G-px) , (GSH), (CP), Uric acid, Albumin in the blood serum of patients with peptic ulcer males and females compared to the control group.
 This study clear that the oxidative stress and free radicals a major role in the development of Peptic ulcer disease.
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