Abstract
Asthma is a chronic in?ammatory respiratory disease associated with the changes of asthmatic airway structural that result from interact remodeling and in?ammatory processes lead to obstruction of airway. Guggulsterone (GS) is a bioactive compound and plant steroid present in guggul gum of Commiphora wightii, which has anti-inflammatory and antioxidant activities. This study designed to investigate of anti-inflammatory activity of gugglsterone in improvement of asthma. Forty eight healthy albino male rats divided to six groups, Group I: Control group (distal water), Group II: Positive control group (distal water) with sensitization, Group III: Guggulsterone (25 mg/kg/day) with sensitization, Group IV: Guggulsterone (50 mg/kg/day) with sensitization, Group V: Prednisolone (4.12 mg/kg/day) with sensitization, Group VI: Guggulsterone (50mg/kg/day) without sensitization. Rats were sacrificed and blood samples were collected to prepare of serum samples that used in ELISA kits for measuring of IL-4, IL-5, IL-33, TNF 
 IgE. In addition, WBC counts in Bronchoalveolar lavage fluid. ALL parameters (IL-4, IL-5, IL-33, TNF, & IgE) levels for rats of treated groups with gugglsterone were significant (P<0.05) reduced in compared to sensitized group. Similarly, WBC count for rats treated groups with guggulsterone was significantly (P<0.05) fewer than sensitized group. In conclusion, our results provide a clue that guggulsterone has a potent anti-inflammatory activity that improved OVA-induced asthma and is useful for the preventive of allergic airway disease in rodents.
Highlights
Asthma is a chronic inflammatory airway remodeling that initiated from simple respiratory disease, associated with changes of thickening to prolong fibrosis.[3] 。The formation of asthmatic airway structures that result from remodeling and inflammatory processes.[1]. In the inflammatory process, common features as exudation, vascular congestion, and inflammatory pro-inflammatory cytokines like IL-4, IL-5, can maintain and initiate the features of disease pathophysiology
1-The effect of Guggulsterone on WBC counts in Bronchoalveolar lavage fluid (BALF) of OVAInduced Asthma in Rats
Series 1 referred to means of WBC counts in BALF for each group
Summary
Asthma is a chronic inflammatory airway remodeling that initiated from simple respiratory disease, associated with changes of thickening to prolong fibrosis.[3] 。The formation of asthmatic airway structures that result from remodeling and inflammatory processes.[1]. IgE, which is stimulating the produce of transcription of cytokines, vasoactive mediators, and de novo synthesis of leukotrienes and prostaglandins on mast cell In the lung these mediators are rapidly evolve mucus production, edema of the bronchial mucosa, and constriction of the smooth muscle and lastly induce an inflammatory infiltrate that lead to inflammatory responses of asthma.[8]. Guggulsterone is a steroid plant (polyphenol) present in guggul gum of Commiphora wightii, which belongs to Burseraceae family and it has two bioactive isomers E- and Z-guggulsterone Both isomers of guggulsterone have antiinflammatory activities by inhibit lipopolysaccharide-induced inflammation through inhibiting NF-κB activation and IκB-α degradation.[9] guggulsterone drastically curbed TNF-induced promoter bounce of COX-2, which is responsible for degradation of arachidonic acid to thromboxane and prostaglandins that lead to inflammatory responses. All these gugglsterone activities may contribute for reducing inflammatory responses associated with asthma
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