STUDY SOME PHYSIOLOGICAL ASPECTS AND HISTOPATHOLOGICAL CHANGES IN MALE RABBITS INTOXICATED BY CHLORPYRIFOS

Abstract

The current experience on chlorpyrifos was undertaken to investigate the potential alterations in Physiological Criteria and in liver and kidney tissues subsequent oral exposure of chlorpyrifos in male rabbits . twelve of male rabbits were employed in this experience, distributed into two groups randomly , group one received only corn oil and served as control, whereas, while group two received CPF 33.3 mg/kg dissolved with( 1ml ) corn oil daily, the exposure continued for 28 consecutive days orally. outcomes of this work revealed that sub-acute oral administration of chlorpyrifos cause to oxidative stress evidenced by pronounced elevation value of oxidative biomarker malondialdehyde ( MDA) concomitantly with elevated in values of inflammatory biomarkers ( TNF-α and CRP) and significantly reduction in total antioxidant capacity (TAC) value, as well as this findings exhibited that chlorpyrifos administration cause to marked alteration of blood indices values as well as histopathological changes were observed in liver and kidney which as represented degenerative of hepatocyte, dilatation and congestion in central vein, While tubular epithelial degenerations, vacuolations and severe dilation in renal cortex tubules. Conclusion: we concluded from findings in this study the oral exposure to CPF evoked inflammation response and oxidative damage as represented by pronounced elevation in levels of CRP,TNF-alpha and MDA biomarkers as well as pathohistological alterations were observably in liver and kidney that indicating that chlorpyrifos elicits numerous adverse effects noteworthy making it a major public health issue.