Abstract
Toll-like receptors represents the first line of defense against foreign pathogens and play an essential role in the innate immune response.Toll-like receptor 9(TLR9) is a major receptor mediating CpG DNA signal transduction, which can not only resist inflammation but also induce inflammatory damage.Studies show that the activation of TLR9 which mediated by endogenous nucleic acid released during viral myocarditis (VMC) can cause the heart damage and be involved in the process of VMC.Further study on the role of TLR9 signal in VMC will provide a theoretical foundation for further revealing the pathogenesis of VMC and seeking effective treatment. Key words: Toll-like receptor 9; Myocarditis; Treatment
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