Abstract
Insulin-like growth factor receptor type 1(IGF-1R) is the receptor cascade effect molecules of IGF signaling pathways in the hypothalamus-pituitary-growth hormone axis.In recent years, IGF-1R gene mutation of short stature case reports increased year by year, now the progress of IGF-1R gene defects in short stature for clinicians was summarized. Key words: Insulin-like growth factor type 1 receptor; Short stature; Growth hormone-insulin-like growth factor axis; Insulin-like growth factor pathway
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