Abstract
The antiviral treatment for children with chronic hepatitis B virus(HBV) infection should be started in the immune active phase.Interferon(IFN) is the drug of first choice in most cases, however, the individual treatment and management of adverse effects need to be considered.Currently, Nucleos(t)ide analogues(NAs) can be used as the first choice only for those special children who can′t use IFN. Efficacy will be seriously affected once the emergence of viral resistance mutants to NAs.However, there is high risk of relapse after the NAs are discontinued.Compared with the mono therapy, the therapeutic strategy of interferon combined with NAs have obtained better effect and safety in children with chronic HBV infection. Key words: Chronic hepatitis B; Interferon; Nucleos(t)ide analogues; Treatment; Child
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