Abstract
In recent years, the incidence of childhood obesity has also increased year by year as people′s living standards keep improving.Over-accumulation of adipose tissue in children with obesity not only affects growth and development, but also increases the risk of certain related metabolic diseases such as insulin resistance and type 2 diabetes.It has been recognized that adipose tissue is the main site of obesity-induced endoplasmic reticulum stress and plays an important role in the development of insulin resistance and type 2 diabetes.As the largest human endocrine organ, adipose tissue will be considered as a key target for the treatment of obesity-related metabolic diseases in children.Now, the mechanism of insulin resistance and type 2 diabetes in children with obesity caused by endoplasmic reticulum stress in adipose tissue were briefly reviewed, and the role of adipose tissue in the development of obesity-associated type 2 diabetes was deeply understanded.It is beneficial for people to actively promote the prevention and treatment of childhood obesity and provide new ideas for clinical treatment of child-related metabolic diseases. Key words: Adipose tissue; Endoplasmic reticulum stress; Child; Obesity; Insulin resistance; Type 2 diabetes
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