Abstract
Elevation of the liver tyrosine: 2-oxoglutarate aminotransferase (EC 2. 6. 1. 5.) activity was observed in Ehrlich ascites tumor bearing mice and also in mice with nonspecific stimuli, such as talcum injection and high protein diet feeding. Regarding the intracellular distribution of the enzyme activity, a higher percentage was demonstrated in the supernatant fraction of mice with acute nonspecific stimuli than in that of the control mice but not in that of mice with tumor. In case of chronic nonspecific stimuli such as repeated talcum injections or feeding on high protein diet for a long term, however the intracellular distribution of enzyme activity resembled that of the control mice. These changes in enzyme activity and its intracellular distribution were found to be closely related to the adrenal steroid hormone.
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