Abstract

Objective To summarize the characteristics of tremor peak frequency, power and harmonics occurrence rate between Parkinson′s disease (PD) and multiple system atrophy-parkinsonism (MSA-P). Methods From January to December in 2016, 48 PD patients and 22 MSA-P patients were enrolled in Beijing Tiantan Hospital. Upper limb tremor patients got tremor analysis test in rest, posture and holding 1 000 g states, while lower limb tremor patients in rest and posture states. Peak frequency, power and harmonics occurrence rate of tremor were compared between PD and MSA-P patients in different states. Results Peak frequency of PD and MSA-P patients in upper rest ((4.76±0.82) Hz vs (6.03±0.25) Hz, t=-2.161, P=0.037), posture ((5.25±0.88) Hz vs (7.66±1.90) Hz, t=-4.266, P=0.001), holding 1 000 g ((5.80±1.28) Hz vs (8.32±1.51) Hz, t=-6.436, P=0.000) and lower posture ((4.85±0.78) Hz vs (6.42±1.13) Hz, t=-3.001, P=0.012) showed statistically significant difference. Half-width power of PD and MSA-P patients in upper rest (extensor: 15.70 (5.82, 32.96) mg2/μV2vs 3.14 (1.69, 4.60) mg2/μV2,Z=-2.008, P=0.037), in posture (extensor: 33.14 (20.46, 64.27) mg2/μV2vs 10.02 (7.11, 14.60) mg2/μV2,Z=-3.627, P=0.000; flexor: 27.49 (9.48, 41.74) mg2/μV2vs 5.97 (4.41, 15.59) mg2/μV2,Z=-2.336, P=0.019), in holding 1 000 g (flexor: 17.80 (9.40, 36.60) mg2/μV2vs 8.15 (5.32, 17.65) mg2/μV2,Z=-2.494, P=0.013), and in lower posture (flexor: 26.63(7.09, 85.84) mg2/μV2vs 3.78 (2.51, 7.12) mg2/μV2,Z=-2.049, P=0.045) showed statistically significant difference. Harmonics occurrence rate of PD and MSA-P patients in rest (82.5% vs 5.9%, χ2=29.096, P=0.000), posture (80.0% vs 5.9%, χ2=26.884, P=0.000) and holding 1 000 g (65.0% vs 0, χ2=20.318, P=0.000) had statistically significant difference. Conclusions Tremor peak frequency in PD patients was lower than that in MSA-P patients, while power and harmonics occurrence rate in PD patients were higher than in MSA-P patients. Key words: Parkinson disease; Multiple system atrophy; Electromyography; Tremor analysis

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