Study on the therapeutic effect of combined use of ant i-silicosis drugs on early experimental silicosis of rats

Abstract

Objective To observe the therapeutic effect of combined use of anti-silicosis drugs on early silicosis of rats. Methods Male Wistar rats were exposed to lower dose(20 mg/rat) of quartz by intr atracheal injection.In the early stage of silicosis,the experimental rats were t reated with 4 single drugs,i.e. poly-2-vinyl pyridine-nitrogen oxide(PVNO),te trandrine(TD),quinolyl-piperazine hydroxyl phosphate(QOHP),aluminium citrate(AL C ) and 3 combined drugs i.e. PVNO+TD,TD+QOHP,ALC+TD for 2 and 5 months respective ly. Results The wet and dry weight and collagen content of w hole rat lung in all of treated groups were obviously lower than that of quartz control groups(P 0.05) except some items on 150 d.Evalutaion by RSR showed th at combined use of ALC+QOHP and TD+QOHP for both 60 d and 150 d were much more e fficient than single use of drugs.Treatment with PVNO+TD for 150 d was also bett er than single use.Pathological examination showed that silicotic lesions of rat lung were much lighter in treated groups than that of quartz groups,and also li ghter 1/2～1 grade in combined use groups as compared to single use groups. Conclusion The therapeutic effects of combined use of anti-s ilicosis drugs on early silicosis were better than those of single drugs.