Study on the structure and properties of Fe3O4@HMPDA@HA magnetic hollow mesoporous submicron drug-carrying system

Abstract

In this study, Fe 3 O 4 @HMPDA@HA core-shell submicron particles with a large specific surface area and total pore volumes were prepared. A large cavity structure was constructed between the core and the shell, so the core-shell particles as drug carriers have a large loading capacity. The adsorption properties and mechanism of organic dyes RhB and MB on particles were studied. The results showed that the adsorption capacities of the particles to RhB and MB were 830.65 mg/g and 380.66 mg/g respectively. And doxorubicin (DOX) was used as a targeted drug to research the delivery and sustained-release properties of the particles, the results showed that the loading capacity of DOX was up to 624.75 mg/g. In addition, Hyaluronic acid (HA) can specifically recognize the cancer cells, so the above prepared particles combined magnetic targeting and receptor-mediated targeting. In vitro experiments, the DOX loaded particles had a significant inhibitory effect on HeLa cells. • A large cavity structure between core and shell endowed the drug carriers a large loading capacity. • HA can specifically recognize the cancer cells. • Fe 3 O 4 nanoparticles endowed the drug carriers a magnetic targeting performance. • The DOX release rate was significantly higher under acidic conditions. • In vitro experiment, the DOX-loaded Fe 3 O 4 @MPDA nanospheres can evidently inhibit the growth of cancer cells.