Study on the Release of Quinine Sulfate from Polylactic Acid/Chitosan/Quinine Sulfate Composite Materials

Abstract

Recently, the polylactic acid /chitosan composite has been used as a drug carrier to regulate the drug release aim to increase effective and decrease drug dosage. Polylactic acid/chitosan composite materials carry 10-50% quinine sulfate was prepared by the water/oil water method to study the release of quinine sulfate. Effects of quinine sulfate content, pH and kinetics of quinine sulphate release were investigated. The results showed that polyacid/chitosan composite materials with high quinine sulfate content for slow speed of release quinine sulfate. The polylactic acid/chitosan composite materials carry 50% quinine sulfate is smallest speed of release quinine sulfate. In pH = 7.4 the release rate of quinine sulfate is greater than the pH = 2.0. The process of releasing quinine sulfate from polylactic acid/chitosan/quinine sulfate composites materials follows the Korsmeyer-Peppas kinetics model and diffuses following the Fick law.
 Keyword
 Release, composite materials, polyaxit lactic, chitosan, quinin sulfat
 References
 [1] Nguyễn Thúy Chinh, Nghiên cứu sự giải phóng thuốc nifedipin được mang bởi vật liệu tổ hợp poly axit lactic/chitosan, Luận án tiến sĩ hóa học, Hà Nội, (2016).[2] Silverajah V.S., Nor A.I., Norhazlin Z., Wan M., Wan Y. and Hazimah A.H., Mechanical, thermal and morphological properties of poly (lactic acid)/ epoxidized palm olein blend, Molecules, 17, 11729, (2012). [3] Gavhane Yogeshkumar N., Gurav Atul S. and Yadav Adhikrao V., Chitosan and its applications: A review of literature, International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(1), pp. 312-331, (2013). [4] Harvie B.F., Poly-L-lactic acid (PLA) in surgery, Philosophy Doctor Thesis, Smith Nephew, First choice in Endoscopy, (2000).[5] Prabaharan M., Rodriguez - Perez M.A., de Saja J.A., Mano J.F., Preparation and characterization of poly (D,L-lactic acid)/ chitosan hybrid scaffold with drug release capability, J. Biomed Mater Res B Appl Biomater, 81(2), pp. 427-434, (2007).[6] Dev A., Binulal N.S., Anitha A., Nair S.V., Fruike T., Tamura H., Jayakumar R., Preparation of poly(lactic acide) nanopaticles for anti-HIV drug delivery applications, Carbohydrate Polymers, 80, pp. 833-838 (2010). [7] Nanda R., Sasmal A., Nayak P.L., Preparation and character-rization of chitosan-polylactide composites blended with Cloisite 30B for control release of the anticancer drug Paclitaxel, CarbohydratePolymers, 83, pp. 988-994, (2011).[8] Portero A., Remunan Lopez C., Vila-Jato J.L., Effect of chitosan and chitosan glutamate enhancing the dissolution properties of the 144 poorly water soluble drug nifedipine, International Journal of Pharmaceutics, 175, pp. 75–84, (1998).