Study on the relationship of urinary liver-type fatty-acid binding protein and progression of nephropathy in diabetic patients

Abstract

Objective To investigate the relationship of urinary liver-type fatty-acid binding protein and progression of ne-phropathy in diabetic patients .Methods A total of 132 cases of type 1 and type 2 diabetic patients were recruited in this study , and were divided into four groups based on the urine albumin /creatinine and serum creatinine levels , including normal albuminuria group （ n =45）, microalbuminuria group （ n =36）, clinical albuminuria group （ n =30）, and renal failure group （ n =21）, Additional 65 healthy subjects were recruited as control group .The levels of urinary liver-type fatty-acid binding protein （ L-FABP） were measured with enzyme-linked immunosorbent assay （ELISA）, and serum creatinine, urine creatinine, Liver function, hemoglobin, glycated he-moglobin （HbA1c）, albumin （Alb）, and 24h urinary protein were measured by respective biochemical or immunological methods . Results With the progression of diabetic nephropathy , the level of urinary L-FABP was gradually increased （ P 0.05）.Conclusions The uri-nary L-FABP level can predict the occurrence of early diabetic nephropathy , and also monitor the progression of diabetic nephropathy . Key words: Diabetic nephropathies/metabolism; Fatty acid-binding proteins; Creatinine/metabolism; Hemoglobin A,glyco-sylated/metabolism; Hemoglobins/metabolism; Albumins/metabolism