Study on the Relationship Between the Imaging Characteristics of Inflammatory Infection and the Expression of Serum Cytokines in Patients with Blood Tumor

Abstract

To study the relationship between the CT image characteristics of inflammatory infection in patients with blood tumor and expression of serum cytokines in patients, and provide a theoretical basis for the application of CT imaging in the diagnosis of inflammation in clinical hematologic tumor patients in the future, 110 patients with inflammatory infection of blood tumor admitted to the hospital from October 30, 2017 to December 30, 2019 were selected as experimental group (EG), and 80 patients without infection in the general blood tumor department were selected as control group (CG). CT imaging was performed on both groups of patients, and two senior doctors read the imaging features and recorded the infection. At the same time, with flow cytometry, levels of IL2, IL-4, IL-6, IL-10, IFN-γ, and TNF-α in serum were detected. Cytokines levels and CT diagnosis results were analyzed by the working characteristic curve of the subjects. Kappa was used to test the consistency of the two physicians, and Spearman correlation was used to analyze the correlation between cytokines and CT diagnosis results. The results demonstrated that IL-6 level, IL-10 level, and TNF-α level in EG were obviously higher than those in CG (P < 0.05), and there was no obvious difference in levels of IL-2, IL-4, and IFN-γ (P > 0.05). The consistency coefficient of kappa test was 0.82. In the EG, sensitivity (Se) and specificity (Spe) of IL-6, IL-10, TNF-α, and CT diagnosis were 53.5% and 76.8%, 53.5% and 80.8%, 53.5% and 72.0%, 86.7% and 72.8%, respectively. Area under curve (AUC) was 0.686, 0.747, 0.657 and 0.859. Spearman correlation analysis (SCA) indicated obvious positive correlation between CT diagnosis results and levels of serum cytokines IL-6, IL-10, and TNF-α in both groups (P < 0.05). The results showed that the levels of IL-6, IL-10 and TNF-α in patients with inflammatory infection were obviously higher than those in patients with common blood tumor. Se and AUC area of CT image diagnosis are the highest, which has a better diagnostic value in inflammatory infection of blood tumor patients. Moreover, it is obviously correlated with cytokines levels, including IL-6, IL-10, and TNF-α, in serum.