Abstract
Aim: To study the relationship between rs1059057 polymorphism of pulmonary surfactant protein A1 (SP-A1) and respiratory distress syndrome (RDS) in Mongolian very premature infants.Methods: Applying the strategy of case-control study, 120 Mongolian RDS very premature infants (58 males and 62 females) in the western part of Inner Mongolia were selected as the case group, and 120 subjects of non-RDS very premature infants (56 males and 64 females) with the same nationality, same sex and similar gestational age were used as the control group. The single nucleotide polymorphism (SNP) site rs1059057 of SP-A1 was genotyped using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP).Results: Two genotypes, A/G and A/A, were detected at the SP-A1 rs1059057 locus in the western part of Inner Mongolia. In the case group, the frequencies of two genotypes were 53 and 47%, and the frequencies of A allele and G allele were 73 and 27%, respectively. In the control group, the frequencies of the two genotypes were 42 and 58%, and the frequencies of A allele and G allele were 79 and 21%, respectively. There was no significant difference in the genotype frequency of SP-A1 (rs1059057) locus between the case group and the control group (X2 = 3.275, P > 0.05), and no significant difference in allele frequency between the case group and the control group (X2 = 2.255, P > 0.05).Conclusion: The genotypes and allele frequencies of SP-A1 (rs1059057) locus were not associated with the incidence of RDS in Mongolian very premature infants in western Inner Mongolia.
Highlights
Neonatal respiratory distress syndrome (NRDS), known as hyaline membrane disease, is mainly due to the lack of pulmonary surfactant (PS), which leads to an increase in alveolar wall surface tension and decreased pulmonary compliance, and initiates newborn’s sexual dyspnea shortly after birth, even clinical syndromes of respiratory failure [1]
The genotypes and allele frequencies of surfactant protein A1 (SP-A1) locus were not associated with the incidence of RDS in Mongolian very premature infants in western Inner Mongolia
This paper mainly introduces the relationship between the gene polymorphism rs1059057 of SP-A1 and the RDS of Mongolian very premature infants, in order to provide help for the rescue of Mongolian very premature infants in the western part of Inner Mongolia
Summary
Neonatal respiratory distress syndrome (NRDS), known as hyaline membrane disease, is mainly due to the lack of pulmonary surfactant (PS), which leads to an increase in alveolar wall surface tension and decreased pulmonary compliance, and initiates newborn’s sexual dyspnea shortly after birth, even clinical syndromes of respiratory failure [1]. NRDS often occurs in premature infants, especially in premature infants within 34 weeks [2]. The probability of NRDS in premature infants with gestational age within 28 weeks is up to 80% [3, 4]. The survival problem of NRDS children has been basically solved, yet prognosis and treatment have remained difficult. The respiratory tract management problems of children with NRDS should not be underestimated, we still need to continue to strive our efforts on them
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