Study on the Relation ship between Helicobacter Pylori Infection and Human Gastric Precancerous Lesions as well as Gastric Cancer

Abstract

Objective To investigate the association of Helicobacter pylori(Hp) infection and human gastric precancerous lesions as well as cancer.Methods Hp infection conditions of chronic atrophic gastritis (CAG),gastric epithelial dysplasia(GED),intestinal metaplasia(IM) and gastric cancer (Ca) in 151 gastric endoscopic biopsy and subtotal gastrectomy specimens were detected by means of Hematoxylin Eosin,Warthin Starrry and HID AB(pH2.5) PAS stainings.Relationship between Hp infection and above mentional lesions were analysed statistically.Results 1)Infection rates of Hp were 66.2%(100/151) in our cases.Hp infection was frequent seen in gastric non cardic mucosa,particularly in antrac area.Infection rates were not association with sexual distinction.(2)Hp infection conditions were not interrelated with the occurrence of CAG,IM Ⅰand Ⅱtype,diffuse type gastric cancer( P 0.05),but were closely correlated with the development of IM Ⅲ type,GED(particularly GED Ⅱ?Ⅲ grade) and intestinal type gastric cancer( P 0.05).Conclusion Hp infection was an important etiologic factor that caused IM Ⅲ type,moderate and server GED as well as intestinal type gastric cancer.