Study on the regulation of immunity by palmitoylation

Abstract

Palmitoylation is a reversible enzymatic post-translational modification of a protein, where the palmitoyl chain connects to cysteine residues via thioester bonds. Palmitoylation affects protein function by affecting protein activity, stability, protein transport, and protein-protein interactions. Palmitoylation occurs in lymphocytes that are critical to both innate and acquired immune responses. Palmitoylation can also occur in the receptors of immune cells, thereby regulating immunity. In this paper, the role of palmitoylation in immunity is summarized by better combing the immune-related signaling pathways affected by palmitoylation.