Study on the Recovery of Exercise-Induced Fatigue by Pressurized Oxygen in Plateau Environment

Abstract

The fatigue recovery is a key factor to determine the effect of altitude training. The research was focused on exercise-induced fatigue of rats training at the altitude of 2260 m (746 MB, 26.35% oxygen partial pressure of air), the training speed was from 25 m/min to 35 m/min, increased by 0 to 10 degrees slope for 1 h in the treadmill, when the rats had significant signs of fatigue, took natural recovery and pressurized oxygen recovery. The results showed that rats had many changes in the high intensity exercise training group with high altitude hypoxia, such as the body weight of rats decreased, exhaustive exercise time shortened, the muscle shape deformated, skeletal muscle hypoxia-inducible factor-1α (HIF-1α) (P ＜ 0.05), myocardial COMR II and brain natriuretic peptide (BNP) (P ＜ 0.01) protein expression decreased, the expression of inducible nitric oxide synthase (iNOS) protein in muscle increased, serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) decreased (P ＜ 0.05) reactive oxygen species (ROS) and malonic dialdehyde (MDA) increased (P ＜ 0.05). While taking pressurized oxygen recovery can prolong the exhaustive exercise time, relieve the change of muscle tissue morphology, increase the myocardial HIF-1α, COMR II and BNP protein expression, decrease the iNOS expression in muscle and serum SOD (P ＜ 0.05), ROS and MDA (P ＜ 0.05) increase the GSH-PX and total anti-oxidative capacity (TAOC), all of which showed that the usage of pressurized oxygen recovery can improve fatigue resistance after fatigue exercise under high altitude hypoxia.