Study on the polymorphism of PPAR-γ gene and preeclampsia susceptibility

Abstract

Objective To investigate the correlation between peroxisome proliferator-activated receptor-gamma (PPAR-γ) gene polymorphism and preeclampsia (PE). Methods 110 PE patients and 110 normal pregnants who delivered in our hospital from May 2016 to October 2018 were selected as the study subjects. Detection of two loci of PPAR-γ gene by SNaPshot technique: rs10865710 and rs4684847. Results ⑴ rs10865710: The genotype frequencies of CC, CG and GG in the control group were 44.55%, 42.73% and 12.73%, respectively, and those in the PE group were 31.82%, 44.55% and 23.64%, respectively. There was a critical difference in the distribution of genotype frequencies between the two groups (χ2=5.975, P=0.050); The frequencies of C and G alleles were 65.91% and 34.09% in the control group, 54.09% and 45.91% in the PE group, respectively. There was significant difference in the frequency distribution of C and G alleles between the two groups (χ2=6.402, P=0.015). ⑵ rs4684847: the genotype frequencies of CC, CT and TT in control group were 94.55%, 5.45%, 0, and those in PE group were 84.55%, 15.45% and 0, respectively, with significant difference in the distribution of genotype frequencies between the two groups (χ2=5.875, P=0.015). The frequencies of C and T alleles in control group were 97.27%, 2.73% and those in PE group were 92.27% and 7.73%, respectively, with significant difference in allele frequency distribution between the two groups (χ2=5.551, P=0.030). ⑶ The frequency of GG genotype and G allele at rs10865710 locus in PE group was significantly higher than that in control group [OR (95% CI)=2.600 (1.190-5.679), P=0.021; OR (95% CI)=1.64 (1.117-2.411), P=0.015]. The frequencies of CT genotype and T allele at rs4684847 locus in PE group were significantly higher than those in control group [OR (95% CI)=3.168 (1.199-8.374), P=0.026; OR (95% CI)=2.987 (1.155-7.726), P=0.030]. Conclusions The single nucleotide polymorphisms of PPAR-γ gene rs10865710 and rs4684847 may be related to the susceptibility to preeclampsia in Chinese population. Key words: Pre-eclampsia; PPAR gamma; Polymorphism, genetic