Study on the polarization pathways of macrophages and related diseases

Abstract

Macrophage is a relatively stable heterogeneous immune cell isolated from monocytes in plasma, which plays a certain role in maintaining stable environment, host defense, phagocytosis and immune information transmission. Under the influence of different environmental factors, macrophages can be polarized into Ml and M2, and this process is reversible. The special phenotype of macrophage polarization can play a role in alleviating or curing the disease, and the polarization process is affected by the stimulation of different signaling pathways [1]. This chapter will review the classical types of macropage polarization, the most important information pathways and regulatory mechanisms, in an attempt to provide a basis for subsequent regulation and the occurrence and progression of lesions.